MEETING No. 19, HELD ON APRIL 12th AT THE MELLONI HOSPITAL, MILAN

Case 2
Case 3

Case 1

"UTERINE CERVIX LESION"
D. RICCI - La Spezia Hospital
(pict. macro by dr. Fedeli, micro by dr. Faravelli)

Clinical history: 47y.o. woman during colposcopy presents a cervical polyp on which a biopsy is performed. Following the biopsy diagnosis a total hysterectomy is performed.
Macroscopic description: the cervix shows a 5 cm polyp (pict. 1) which occupies the entire endocervical canal.
Microscopic description: the lesion is relatively well defined and consists of a solid proliferation of atypical , even if monomorphic, spindled cells which show a high mitotic index (7/HPF) (pict. 2) - (pict. 3) - (pict. 4).
At the periphery of the lesion, towards the muscular layer the tumor cells show large cytoplasm and rather atypical nuclei (pict. 5) - (pict. 6) - (pict. 7).
There are also sparse micro-cystic spaces, lined by cuboidal epithelium with polypoid projections into the lumens (pict. 8) - (pict. 9).
The neoplastic cells are positive with immunocytochemical staining for Vimentin and focally for protein S-100, in particular around the pseudo-cystic areas (pict. 10) - (pict. 11); immunocytochemical staining with antisera for Actin and Desmin are negative.
Staining for Estrogen receptors is positive in the epithelial cells nuclei while the neoplastic cells are negative (pict. 12).

Diagnosis

pict. 1	pict. 2
pict. 3	pict. 4
pict. 5	pict. 6
pict. 7	pict. 8
pict. 9	pict. 10
pict. 11	pict. 12

Click here to send your comments.