MEETING No. 30, APRIL 11th, FATEBENEFRATELLI HOSPITAL, MILAN

Case 1
Case 2
Case 3

Caso 3

"THYROID MASS"
A.M. CROCE - Fatebenefratelli Hospital - Milano
(pict. by F.Bianchi)

Clinical history: in November 2000 a 54y.o. man presents with a rapidly growing mass in the thyroid left lobe and isthmus, which infiltrates the surrounding tissue. A chest CT scan is negative. An abdominal ultrasound reveals a solitary, 3 cm, liver nodule. A thyroid FNA and a liver needle biopsy are performed.
Microscopic description of the cytological specimen: the smear is very cellular and shows pleomorphic elements, with abundant cytoplasm, irregular nuclei and prominent nucleoli (pict. 1) - (pict. 2).
Microscopic description of the liver biopsy: the liver parenchyma is completely replaced by large spindled cell, with irregular nuclei and prominent nucleoli. Mitoses are frequent (pict. 3) - (pict. 4). These cells are positive for cam 5.2 Cytokeratin, (pict. 5) and for Laminin (pict. 6) and they are negative for EMA, S100, HMB 45, CD 34, and CD31.

Diagnosis

pict. 1	pict. 2
pict. 3	pict. 4
pict. 5	pict. 6
pict. 7	pict. 8
pict. 9	pict. 10

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