MEETING No. 39, FEBRUARY 13th, NATIONAL CANCER INSTITUTE, MILANO

Case 1
Case 2
Case 3
Case 4

Case 4


"ESOPHAGEAL POLYP"
C. GALLI - Niguarda Hospital - Milano
(pict. by dr. Giardini)

Clinical history: a 71y.o. woman with a history of esophageal polyp, which is removed during endoscopy.
Microscopical description: underneath the normal appearing, squamous esophageal epithelium there is a proliferation of cell, arranged in trabecular or pseudo-glandular structures, with large eosinophilic cytoplasm and regular, round nuclei.
No mitoses are seen (pict. 1 - pict. 2 - pict. 3).
The neoplastic cells are positive with immunohistochemical staining for Chromogranin, Synaptophysin and focally for Cytokeratin; they are negative for S100.
The anamnesis reveals that the patient in 1988 had a thyroidectomy for “follicular carcinoma” with capsular and vascular invasion and that in 1999 she had a local recurrence of the disease, which was diagnosed as metastatic follicular carcinoma.
The histological slides of the 1988 and 1999 surgical operations are revised and they show a morphological picture similar to the actual esophageal neoplasia (pict. 4 - pict. 5).
Immunohistochemical staining of the histological section of the 1988 case show Thyroglobulin (pict. 6), Chromogranin and Synaptophysin positive neoplastic cells; they are negative for Calcitonin. Thyroglobulin is also positive in the neoplastic cells of the esophageal tumor.

Diagnosis

pict. 1	pict. 2
pict. 3	pict. 4
pict. 5	pict. 6

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