MEETING No. 45 - SEPTEMBER 11th, 2002 - NIGUARDA HOSPITAL, MILAN

Case 1
Case 2
Case 3
Case 4
Case 5

Case 1


“THORACIC MASS”
G. ARRIGONI – Ospedale S. Raffaele - Milano
(pict. by dr. Arrigoni)

Clinical history: 57y.o.man with recurrent pleural effusion and X-Ray showing right diffuse pleural thickening with lung compression. The cytological examination of the pleural effusion is negative for neoplastic cells, so the patient undergoes thoracoscopy and biopsy.
Macroscopical description: Numerous white-greyish fragments, the biggest 1.8cm in dimension, are sent.
Microscopical description: In a dense stroma there are medium-large size cells, which form nests or which line optically empty spaces (pict. 1 - pict. 2 - pict. 3); they have large, clear or eosinophilic, sometimes vacuolated cytoplasm, with hyperchromatic and irregular nuclei, sometimes with prominent nucleoli; there are no mitoses and necrosis (pict. 4 - pict. 5).
The neoplastic cells are Vimentin, CD31 (pict. 6 - pict. 7) and CD34 (pict. 8 - pict. 9) positive, occasionally they are positive for pool Cytokeratin (pict. 10) but they are negative for Calretinin, EMA, CEA and TTF-1.

Diagnosis

pict. 1	pict. 2
pict. 3	pict. 4
pict. 5	pict. 6
pict. 7	pict. 8
pict. 9	pict. 10

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